Molecular pathology

Detection of mutations and fusions in the FGFR1, FGFR2, FGFR3 and FGFR4 genes

The AmoyDx^® HANDLE Melanoma NGS Panel is a Next-Generation Sequencing-based assay for the qualitative detection of mutations (SNVs), insertions and deletions (InDels) in nine key genes that play a decisive role in the analysis of malignant melanomas. In addition to the detection of common biomarkers such as BRAF, NRAS, KIT, GNA11 and GNAQ, mutations in two critical hotspot areas of the TERT promoter (C228T, C250T) are also detected

The newly available AmoyDx^® Myeloid Blood Cancer Panel enables a comprehensive molecular genetic analysis of 55 genes associated with myeloid leukemia. The analysis on both DNA and RNA level permits the detection of 252 different gene fusions in addition to single nucleotide variants (SNVs), and insertions and deletions (InDels).

The AmoyDx^® HRD Complete Panel is an advanced development of the AmoyDx^® HRD Focus Panel, which is already established in many laboratories for determining homologous recombination deficiency (HRD). In both NGS assays, in addition to the BRCA1/2 mutational status, genomic instability is determined based on 24,000 SNPs, which are evenly distributed throughout the genome. An algorithm generated by machine learning uses these SNPs to calculate a Genomic Scar Score (GSS).

Genotyping of mycobacteria

The VisionArray ^® MYCO Chip 2.0 of our sister company ZytoVision is a DNA array for the detection of mycobacteria.

Combined detection of mutations in BRCA1/BRCA2 and determination of the HRD status

Workstation and Analysis Software for AmoyDx® NGS Kits

Genotyping of human papilloma viruses

We offer the VisionArray ^® DNA chip system of our sister company ZytoVision for HPV detection.